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How is the Toxicity of New Cosmetic Ingredients "Calculated"? - A Technical Analysis of Computational Models for Predicting New Ingredient Toxicity
Since the concept of New Approach Methodologies (NAMs) was introduced, various methods including in vitro approaches, Threshold of Toxicological Concern (TTC), and computational models have gained favor among toxicological assessment experts. With the increasing capabilities of computational models, key toxicological endpoints such as acute toxicity, skin/eye irritation, sensitization, chronic toxicity, genotoxicity, carcinogenicity, reproductive and developmental toxicity, and toxicokinetics can now be predicted using QSAR models.
10-09
Interpretation of the New Regulatory Requirements for Hair Dye Cosmetics in China
On July 31, 2025, the National Institutes for Food and Drug Control (NIFDC) released six Technical Guidelines, including the Technical Guidelines for the Study of Hair Dye Cosmetics (Trial) (Draft for Comments), to solicit public opinions. The following is a detailed interpretation of the Technical Guidelines for the Study of Hair Dye Cosmetics (Trial) (Draft for Comments) and the Technical Guidelines for the Study of Quality Control Standards for Hair Dye Cosmetics (Trial). This aims to assist enterprises in keeping up with regulatory and policy changes in a timely manner, ensuring smooth adaptation to regulatory developments.
09-23
Brazil Bans Animal Testing for Cosmetics and Personal Care Products
On July 30, 2025, Brazil enacted a landmark regulation prohibiting the use of animals for testing cosmetics, personal care products, perfumes, and their ingredients.
09-02
New Compliance Requirements to be Introduced for Perm Hair Products in China
On July 31, 2025, the National Institutes for Food and Drug Control (NIFDC) released six draft Technical Guidelines for public consultation, including the Technical Guidelines for the Study of Hair Dye Cosmetics (Trial). In terms of perm hair cosmetics, according to the relevant guidelines, the definition and classification of them have been clarified.
09-01
Why choose CIRS Biotech?
Global Resources
With HQs in China, CIRS Group has branch companies in USA, UK, France, Korea, Japan, Ireland, that can provide cutting edge technical information and support to our clients
Rich Experience
CIRS Group has 17 years accumulation on testing and compliance service technical abilities. CIRS Group has served more than 20,000 clients, including 60+ world top 500 companies
One-Stop-Service Capability
Service range includes cosmetic ingredient development, physical/chemical tests, in-vivo toxicological tests, toxicology risk assessment, in-vitro toxicological study, clinical efficacy study, in-vitro efficacy study, raw material registration, product registration and etc.
Experts Team
Technical team built with experts from personal care industry, College Professor, Risk Assessment Expert, Toxicological Expert, Regulatory Compliance Expert
Professional Equipment and Technique
Capability includes the professional instruments and techniques for in-vitro efficacy study, in-vitro safety study, clinical efficacy study, in-vitro study method development, ingredient development and improvement
Why choose CIRS Biotech?
01
Global Resources
With HQs in China, CIRS Group has branch companies in USA, UK, France, Korea, Japan, Ireland, that can provide cutting edge technical information and support to our clients
02
Rich Experience
CIRS Group has 17 years accumulation on testing and compliance service technical abilities. CIRS Group has served more than 20,000 clients, including 60+ world top 500 companies
03
Experts Team
Technical team built with experts from personal care industry, College Professor, Risk Assessment Expert, Toxicological Expert, Regulatory Compliance Expert
04
One-Stop-Service Capability
Service range includes cosmetic ingredient development, physical/chemical tests, in-vivo toxicological tests, toxicology risk assessment, in-vitro toxicological study, clinical efficacy study, in-vitro efficacy study, raw material registration, product registration and etc.
05
Professional Equipment and Technique
Capability includes the professional instruments and techniques for in-vitro efficacy study, in-vitro safety study, clinical efficacy study, in-vitro study method development, ingredient development and improvement